Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?

Reducing infarct size (IS) by interfering with mechanisms for cardiomyocyte death remains an elusive goal. DMX-5804, a selective inhibitor of the stress-activated kinase MAP4K4, suppresses cell death in mouse myocardial infarction (MI), human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs),...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: te Lintel Hekkert , Maaike, Newton, Gary, Chapman, Kathryn, Aqil, Rehan, Downham, Robert, Yan, Robert, Merkus, Daphne, Whitlock, Gavin, Lane, Charlotte A. L., Cawkill, Darren, Perrior, Trevor, Duncker, Dirk J., Schneider, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137473/
https://ncbi.nlm.nih.gov/pubmed/34018053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00875-7
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