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Predicting mean ribosome load for 5’UTR of any length using deep learning

The 5’ untranslated region plays a key role in regulating mRNA translation and consequently protein abundance. Therefore, accurate modeling of 5’UTR regulatory sequences shall provide insights into translational control mechanisms and help interpret genetic variants. Recently, a model was trained on...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Karollus, Alexander, Avsec, Žiga, Gagneur, Julien
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8136849/
https://ncbi.nlm.nih.gov/pubmed/33970899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008982
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