An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics

While engineered chimeric antigen receptor (CAR) T cells have shown promise in detecting and eradicating cancer cells within patients, it remains difficult to identify a set of truly cancer-specific CAR-targeting cell surface antigens to prevent potentially fatal on-target off-tumor toxicity against...

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Dettagli Bibliografici
Pubblicato in:ACS Synth Biol
Autori principali: Allen, Molly E., Zhou, Wei, Thangaraj, Jeyan, Kyriakakis, Phillip, Wu, Yiqian, Huang, Ziliang, Ho, Phuong, Pan, Yijia, Limsakul, Praopim, Xu, Xiangdong, Wang, Yingxiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135225/
https://ncbi.nlm.nih.gov/pubmed/31592660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.9b00175
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