Prohibitin depletion extends lifespan of a TORC2/SGK‐1 mutant through autophagy and the mitochondrial UPR

Mitochondrial prohibitins (PHB) are highly conserved proteins with a peculiar effect on lifespan. While PHB depletion shortens lifespan of wild‐type animals, it enhances longevity of a plethora of metabolically compromised mutants, including target of rapamycin complex 2 (TORC2) mutants sgk‐1 and ri...

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發表在:Aging Cell
Main Authors: de la Cruz‐Ruiz, Patricia, Hernando‐Rodríguez, Blanca, Pérez‐Jiménez, Mercedes M., Rodríguez‐Palero, María Jesús, Martínez‐Bueno, Manuel D., Pla, Antoni, Gatsi, Roxani, Artal‐Sanz, Marta
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2021
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8135086/
https://ncbi.nlm.nih.gov/pubmed/33939875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13359
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