Saponins from Panax japonicus ameliorate age-related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2-ARE signaling

BACKGROUND: The decreased renal function is known to be associated with biological aging, of which the main pathological features are chronic inflammation and renal interstitial fibrosis. In previous studies, we reported that total saponins from Panax japonicus (SPJs) can availably protect acute myo...

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Detalhes bibliográficos
Publicado no:J Ginseng Res
Main Authors: Gao, Yan, Yuan, Ding, Gai, Liyue, Wu, Xuelian, Shi, Yue, He, Yumin, Liu, Chaoqi, Zhang, Changcheng, Zhou, Gang, Yuan, Chengfu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8134850/
https://ncbi.nlm.nih.gov/pubmed/34025134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgr.2020.08.005
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