Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

Aberrant activation of Wnt/β-catenin pathway is a key driver of colorectal cancer (CRC) growth and of great therapeutic importance. In this study, we performed comprehensive CRISPR screens to interrogate the regulatory network of Wnt/β-catenin signaling in CRC cells. We found marked discrepancies be...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Wan, Chunhua, Mahara, Sylvia, Sun, Claire, Doan, Anh, Chua, Hui Kheng, Xu, Dakang, Bian, Jia, Li, Yue, Zhu, Danxi, Sooraj, Dhanya, Cierpicki, Tomasz, Grembecka, Jolanta, Firestein, Ron
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133758/
https://ncbi.nlm.nih.gov/pubmed/34138730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf2567
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