Dissecting the Transcriptional and Chromatin Accessibility Heterogeneity of Proliferating Cone Precursors in Human Retinoblastoma Tumors by Single Cell Sequencing—Opening Pathways to New Therapeutic Strategies?

PURPOSE: Retinoblastoma (Rb) is a malignant neoplasm arising during retinal development from mutations in the RB1 gene. Loss or inactivation of both copies of RB1 results in initiation of retinoblastoma tumors; however, additional genetic changes are needed for the continued growth and spread of the...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Collin, Joseph, Queen, Rachel, Zerti, Darin, Steel, David H, Bowen, Claire, Parulekar, Manoj, Lako, Majlinda
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2021
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132003/
https://ncbi.nlm.nih.gov/pubmed/34003213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.6.18
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