Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney

The epoxyeicosatrienoic acid (EET) exerts beneficial effects on insulin resistance and/or hypertension. EETs could be readily converted to less biological active diols by soluble epoxide hydrolase (sEH). However, whether sEH inhibition can ameliorate the comorbidities of insulin resistance and hyper...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Luo, Jinlan, Hu, Shuiqing, Fu, Menglu, Luo, Liman, Li, Yuanyuan, Li, Wenhua, Cai, Yueting, Dong, Ruolan, Yang, Yan, Tu, Ling, Xu, Xizhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131320/
https://ncbi.nlm.nih.gov/pubmed/33864813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100667
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