Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model

The mechanistic neuropharmacokinetic (neuroPK) model was established to predict unbound brain-to-plasma partitioning (K(p,uu,brain)) by considering in vitro efflux activities of multiple drug resistance 1 (MDR1) and breast cancer resistance protein (BCRP). Herein, we directly compare this model to a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:AAPS J
Hlavní autoři: Kosugi, Yohei, Mizuno, Kunihiko, Santos, Cipriano, Sato, Sho, Hosea, Natalie, Zientek, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131289/
https://ncbi.nlm.nih.gov/pubmed/34008121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-021-00604-x
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky