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Assessing vesicular monoamine transport and toxicity using fluorescent false neurotransmitters
Impairments in the vesicular packaging of dopamine result in an accumulation of dopamine in the cytosol. Cytosolic dopamine is vulnerable to two metabolic processes - enzymatic catabolism and enzymatic- or auto-oxidation - that form toxic metabolites and generate reactive oxygen species. Alterations...
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| Pubblicato in: | Chem Res Toxicol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8131219/ https://ncbi.nlm.nih.gov/pubmed/33378168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.0c00380 |
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