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Whole-genome sequencing analysis of CNV using low-coverage and paired-end strategies is efficient and outperforms array-based CNV analysis

BACKGROUND: Copy number variation (CNV) analysis is an integral component of the study of human genomes in both research and clinical settings. Array-based CNV analysis is the current first-tier approach in clinical cytogenetics. Decreasing costs in high-throughput sequencing and cloud computing hav...

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Detalhes bibliográficos
Publicado no:J Med Genet
Main Authors: Zhou, Bo, Ho, Steve S, Zhang, Xianglong, Pattni, Reenal, Haraksingh, Rajini R, Urban, Alexander E
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131063/
https://ncbi.nlm.nih.gov/pubmed/30061371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2018-105272
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