Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats

Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis in the colorectum. This study aimed to investigate the chemopreventive ability of RQ-15986, a selective EP4 antagonist, in colitis-related colorectal tumorigenesis. Male Kyoto APC delta rats, which have APC mutations...

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Veröffentlicht in:PLoS One
Hauptverfasser: Shirakami, Yohei, Nakanishi, Takayuki, Ozawa, Noritaka, Ideta, Takayasu, Kochi, Takahiro, Kubota, Masaya, Sakai, Hiroyasu, Ibuka, Takashi, Tanaka, Takuji, Shimizu, Masahito
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130959/
https://ncbi.nlm.nih.gov/pubmed/34003864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251942
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