Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children

For the management of iatrogenic withdrawal syndrome (IWS) in children, a quantitative understanding of the dynamics of IWS of commonly used opioids and sedatives is lacking. Here, we introduce a new mechanism-based pharmacokinetic-pharmacodynamic (PKPD) modeling approach for studying IWS in pediatr...

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Bibliographic Details
Published in:AAPS J
Main Authors: Goulooze, Sebastiaan C., Ista, Erwin, van Dijk, Monique, Tibboel, Dick, Krekels, Elke H. J., Knibbe, Catherijne A. J.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128736/
https://ncbi.nlm.nih.gov/pubmed/34002290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-021-00586-w
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