OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

Adrenergic stimulation of brown adipocytes alters mitochondrial dynamics, including the mitochondrial fusion protein optic atrophy 1 (OPA1). However, direct mechanisms linking OPA1 to brown adipose tissue (BAT) physiology are incompletely understood. We utilized a mouse model of selective OPA1 delet...

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Bibliographic Details
Published in:eLife
Main Authors: Pereira, Renata O, Marti, Alex, Olvera, Angela Crystal, Tadinada, Satya Murthy, Bjorkman, Sarah Hartwick, Weatherford, Eric Thomas, Morgan, Donald A, Westphal, Michael, Patel, Pooja H, Kirby, Ana Karina, Hewezi, Rana, Bùi Trân, William, García-Peña, Luis Miguel, Souvenir, Rhonda A, Mittal, Monika, Adams, Christopher M, Rahmouni, Kamal, Potthoff, Matthew J, Abel, E Dale
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2021
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128440/
https://ncbi.nlm.nih.gov/pubmed/33944779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.66519
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