New link between the RNA polymerase II-CTD and replication stress

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

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Veröffentlicht in:Mol Cell Oncol
Hauptverfasser: Landsverk, Helga B., Sandquist, Lise E., Bay, Lilli T. E., Syljuåsen, Randi G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8128203/
https://ncbi.nlm.nih.gov/pubmed/34027044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2021.1910008
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