Pyridazinone derivatives as potential anti-inflammatory agents: synthesis and biological evaluation as PDE4 inhibitors

Cyclic nucleotide phosphodiesterase type 4 (PDE4), which controls the intracellular level of cyclic adenosine monophosphate (cAMP), has aroused scientific attention as a suitable target for anti-inflammatory therapy of respiratory diseases. This work describes the development and characterization of...

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Detalhes bibliográficos
Publicado no:RSC Med Chem
Main Authors: Allart-Simon, Ingrid, Moniot, Aurélie, Bisi, Nicolo, Ponce-Vargas, Miguel, Audonnet, Sandra, Laronze-Cochard, Marie, Sapi, Janos, Hénon, Eric, Velard, Frédéric, Gérard, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: RSC 2021
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127987/
https://ncbi.nlm.nih.gov/pubmed/34046629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0md00423e
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