SMAD4 Expression in Renal Cell Carcinomas Correlates With a Stem-Cell Phenotype and Poor Clinical Outcomes

Renal cell carcinoma (RCC) is the most lethal neoplasm of common urologic cancers with poor prognoses. SMAD4 has a principal role in TGF-β (Transformis growth factorβ)-induced epithelial to mesenchymal transition (EMT) as a key factor in gaining cancer stem cell (CSC) features and tumor aggressivene...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Rasti, Arezoo, Madjd, Zahra, Saeednejad Zanjani, Leili, Babashah, Sadegh, Abolhasani, Maryam, Asgari, Mojgan, Mehrazma, Mitra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127783/
https://ncbi.nlm.nih.gov/pubmed/34012911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.581172
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