A higher flexibility at the SARS-CoV-2 main protease active site compared to SARS-CoV and its potentialities for new inhibitor virtual screening targeting multi-conformers

The main-protease (M(pro)) catalyzes a crucial step for the SARS-CoV-2 life cycle. The recent SARS-CoV-2 presents the main protease (M(CoV2)(pro)) with 12 mutations compared to SARS-CoV (M(CoV1)(pro)). Recent studies point out that these subtle differences lead to mobility variances at the active si...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biomol Struct Dyn
Egile Nagusiak: Rocha, Rafael E. O., Chaves, Elton J. F., Fischer, Pedro H. C., Costa, Leon S. C., Grillo, Igor Barden, da Cruz, Luiz E. G., Guedes, Fabiana C., da Silveira, Carlos H., Scotti, Marcus T., Camargo, Alex D., Machado, Karina S., Werhli, Adriano V., Ferreira, Rafaela S., Rocha, Gerd B., de Lima, Leonardo H. F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8127201/
https://ncbi.nlm.nih.gov/pubmed/33970798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2021.1924271
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