Centrosome‐mediated microtubule remodeling during axon formation in human iPSC‐derived neurons

Axon formation critically relies on local microtubule remodeling and marks the first step in establishing neuronal polarity. However, the function of the microtubule‐organizing centrosomes during the onset of axon formation is still under debate. Here, we demonstrate that centrosomes play an essenti...

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Vydáno v:EMBO J
Hlavní autoři: Lindhout, Feline W, Portegies, Sybren, Kooistra, Robbelien, Herstel, Lotte J, Stucchi, Riccardo, Hummel, Jessica J A, Scheefhals, Nicky, Katrukha, Eugene A, Altelaar, Maarten, MacGillavry, Harold D, Wierenga, Corette J, Hoogenraad, Casper C
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126955/
https://ncbi.nlm.nih.gov/pubmed/33835529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106798
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