Immune evasion in HPV(−) head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while conversely being associated with immune suppression and cytotoxic-cell depletion in human tumors, especially head and neck cancer (HNSC). We prese...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: William, William N., Zhao, Xin, Bianchi, Joy J., Lin, Heather Y., Cheng, Pan, Lee, J. Jack, Carter, Hannah, Alexandrov, Ludmil B., Abraham, Jim P., Spetzler, David B., Dubinett, Steven M., Cleveland, Don W., Cavenee, Webster, Davoli, Teresa, Lippman, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126856/
https://ncbi.nlm.nih.gov/pubmed/33952700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2022655118
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