Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains

Intranasal (i.n.) immunization is a promising vaccination route for infectious respiratory diseases such as influenza. Recombinant protein vaccines can overcome the safety concerns and long production phase of virus-based influenza vaccines. However, soluble protein vaccines are poorly immunogenic i...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Dong, Chunhong, Wang, Ye, Gonzalez, Gilbert X., Ma, Yao, Song, Yufeng, Wang, Shelly, Kang, Sang-Moo, Compans, Richard W., Wang, Bao-Zhong
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126854/
https://ncbi.nlm.nih.gov/pubmed/33941704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024998118
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