Impaired inhibitory GABAergic synaptic transmission and transcription studied in single neurons by Patch-seq in Huntington’s disease

Transcriptional dysregulation in Huntington’s disease (HD) causes functional deficits in striatal neurons. Here, we performed Patch-sequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic transmission and gene transcription in single striatal...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Paraskevopoulou, Foteini, Parvizi, Poorya, Senger, Gökçe, Tuncbag, Nurcan, Rosenmund, Christian, Yildirim, Ferah
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126788/
https://ncbi.nlm.nih.gov/pubmed/33952696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2020293118
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