Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biological Samples

The metabolic ratios lactate/pyruvate and β-hydroxybutyrate/acetoacetate are considered valuable tools to evaluate the in vivo redox cellular state by estimating the free NAD+/NADH in cytoplasm and mitochondria, respectively. The aim of the current study was to validate a gas-chromatography mass spe...

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Publicado en:Int J Mol Sci
Autores principales: Wijngaard, Robin, Perramón, Meritxell, Parra-Robert, Marina, Hidalgo, Susana, Butrico, Gina, Morales-Ruiz, Manuel, Zeng, Muling, Casals, Eudald, Jiménez, Wladimiro, Fernández-Varo, Guillermo, Shulman, Gerald I., Cline, Gary W., Casals, Gregori
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125771/
https://ncbi.nlm.nih.gov/pubmed/33946157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094752
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