The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation

Heterotypic interactions between newly transformed cells and normal surrounding cells define tumor’s fate in incipient carcinomas. Once homeostasis has been lost, normal resident fibroblasts become carcinoma-associated fibroblasts, conferring protumorogenic properties on these normal cells. Here we...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Díaz-Maroto, Natalia Guillén, Garcia-Vicién, Gemma, Polcaro, Giovanna, Bañuls, María, Albert, Nerea, Villanueva, Alberto, Molleví, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8125420/
https://ncbi.nlm.nih.gov/pubmed/34066976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22094960
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