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Advances in Predictions of Oral Bioavailability of Candidate Drugs in Man with New Machine Learning Methodology

Oral bioavailability (F) is an essential determinant for the systemic exposure and dosing regimens of drug candidates. F is determined by numerous processes, and computational predictions of human estimates have so far shown limited results. We describe a new methodology where F in humans is predict...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Fagerholm, Urban, Hellberg, Sven, Spjuth, Ola
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8124353/
https://ncbi.nlm.nih.gov/pubmed/33925103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26092572
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