Multiregional Sequencing of IDH-WT Glioblastoma Reveals High Genetic Heterogeneity and a Dynamic Evolutionary History

SIMPLE SUMMARY: Glioblastoma is the most common and aggressive primary brain malignancy in adults. In addition to extensive inter-patient heterogeneity, glioblastoma shows intra-tumor extensive cellular and molecular heterogeneity, both spatially and temporally. This heterogeneity is one of the main...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Franceschi, Sara, Civita, Prospero, Pasqualetti, Francesco, Lessi, Francesca, Modena, Martina, Barachini, Serena, Morelli, Mariangela, Santonocito, Orazio, Vannozzi, Riccardo, Pilkington, Geoffrey J., Ortenzi, Valerio, Naccarato, Antonio Giuseppe, Aretini, Paolo, Mazzanti, Chiara Maria
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122908/
https://ncbi.nlm.nih.gov/pubmed/33922652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13092044
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