Psychedelic-Inspired Drug Discovery Using an Engineered Biosensor

Ligands can induce G protein-coupled receptors (GPCRs) to adopt a myriad of conformations, many of which play critical roles in determining the activation of specific signaling cascades associated with distinct functional and behavioral consequences. For example, the 5-hydroxytryptamine 2A receptor...

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Vydáno v:Cell
Hlavní autoři: Dong, Chunyang, Ly, Calvin, Dunlap, Lee E., Vargas, Maxemiliano V., Sun, Junqing, Hwang, In-Wook, Azinfar, Arya, Oh, Won Chan, Wetsel, William C., Olson, David E., Tian, Lin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8122087/
https://ncbi.nlm.nih.gov/pubmed/33915107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.03.043
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