Circulating neprilysin hypothesis: A new opportunity for sacubitril/valsartan in patients with heart failure and preserved ejection fraction?

BACKGROUND: Circulating Neprilysin (sNEP) has emerged as a potential prognostic biomarker in heart failure (HF). In PARAGON-HF benefit of sacubitril/valsartan was only observed in patients with left ventricular ejection fraction (LVEF) ≤57%. We aimed to assess the prognostic value of sNEP in outpati...

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Udgivet i:PLoS One
Main Authors: Lupón, Josep, Santiago-Vacas, Evelyn, Cediel, Germán, Codina, Pau, Domingo, Mar, Revuelta-López, Elena, Zamora, Elisabet, Spitaleri, Giosafat, Santesmases, Javier, Núñez, Julio, Bayes-Genis, Antoni
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8121351/
https://ncbi.nlm.nih.gov/pubmed/33989294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0249674
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