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Retracing our steps to understand ketamine in depression: A focused review of hypothesized mechanisms of action

INTRODUCTION: MDD represents a significant burden worldwide, and while a number of approved treatments exist, there are high rates of treatment resistance and refractoriness. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist, is a novel, rapid-acting antidepressant, however the mechanism...

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Detalhes bibliográficos
Publicado no:Ment Health Clin
Main Authors: Irwin, Madison N., VandenBerg, Amy
Formato: Artigo
Idioma:Inglês
Publicado em: College of Psychiatric & Neurologic Pharmacists 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120982/
https://ncbi.nlm.nih.gov/pubmed/34026396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.9740/mhc.2021.05.200
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