Inner retinal injury in experimental glaucoma is prevented upon AAV mediated Shp2 silencing in a caveolin dependent manner

SH2 domain containing tyrosine phosphatase 2 (Shp2; PTPN11) regulates several intracellular pathways downstream of multiple growth factor receptors. Our studies implicate that Shp2 interacts with Caveolin-1 (Cav-1) protein in retinal ganglion cells (RGCs) and negatively regulates BDNF/TrkB signaling...

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Sparad:
Bibliografiska uppgifter
I publikationen:Theranostics
Huvudupphovsmän: Abbasi, Mojdeh, Gupta, Vivek K., Chitranshi, Nitin, Gupta, Veer, Ranjbaran, Reza, Rajput, Rashi, Pushpitha, Kanishka, KB, Devaraj, You, Yuyi, Salekdeh, Ghasem Hosseini, Parton, Robert G., Mirzaei, Mehdi, Graham, Stuart L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Ivyspring International Publisher 2021
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120201/
https://ncbi.nlm.nih.gov/pubmed/33995651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55472
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