Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge

Fentanyl is a major contributor to the devastating increase in overdose deaths from substance use disorders (SUD). A vaccine targeting fentanyl could be a powerful immunotherapeutic. Here, we evaluated adjuvant and delivery strategies for conjugate antigen vaccination with fentanyl-based haptens. We...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Stone, Addison E., Scheuermann, Sarah E., Haile, Colin N., Cuny, Gregory D., Velasquez, Marcela Lopez, Linhuber, Joshua P., Duddupudi, Anantha L., Vigliaturo, Jennifer R., Pravetoni, Marco, Kosten, Therese A., Kosten, Thomas R., Norton, Elizabeth B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119695/
https://ncbi.nlm.nih.gov/pubmed/33986280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-021-00329-0
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