Prevention of D-GalN/LPS-induced ALI by 18β-glycyrrhetinic acid through PXR-mediated inhibition of autophagy degradation

Acute liver injury (ALI) has multiple causes and results in liver dysfunction. Severe or persistent liver injury eventually leads to liver failure and even death. Pregnane X receptor (PXR)-null mice present more severe liver damage and lower rates of autophagy. 18β-glycyrrhetinic acid (GA) has been...

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Publicat a:Cell Death Dis
Autors principals: Wu, Shouyan, Lu, Henglei, Wang, Wenjie, Song, Luyao, Liu, Meng, Cao, Yuhan, Qi, Xinming, Sun, Jianhua, Gong, Likun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119493/
https://ncbi.nlm.nih.gov/pubmed/33986260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03768-8
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