A human Myogenin promoter modified to be highly active in alveolar rhabdomyosarcoma drives an effective suicide gene therapy

Rhabdomyosarcoma is a rare childhood soft tissue cancer whose cells resemble poorly differentiated skeletal muscle, expressing myogenic proteins including MYOGENIN. Alveolar rhabdomyosarcoma (ARMS) accounts for ~40% of cases and is associated with a poorer prognosis than other rhabdomyosarcoma varia...

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Vydáno v:Cancer Gene Ther
Hlavní autoři: Pruller, Johanna, Hofer, Isabella, Ganassi, Massimo, Heher, Philipp, Ma, Michelle T., Zammit, Peter S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group US 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119243/
https://ncbi.nlm.nih.gov/pubmed/32973362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-020-00225-0
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