The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC is frequently associated with a t(11;19)(q14-21;p12-13) translocation that creates a CRTC1-MAML2 fusion gene. The CRTC1...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Chen, Zirong, Ni, Wei, Li, Jian-Liang, Lin, Shuibin, Zhou, Xin, Sun, Yuping, Li, Jennifer W., Leon, Marino E., Hurtado, Maria D., Zolotukhin, Sergei, Liu, Chen, Lu, Jianrong, Griffin, James D., Kaye, Frederic J., Wu, Lizi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119194/
https://ncbi.nlm.nih.gov/pubmed/33830080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139497
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