Relationship Between the Free and Total Methotrexate Plasma Concentration in Children and Application to Predict the Toxicity of HD-MTX

High-dose methotrexate (HD-MTX) can be highly effective as well as extremely toxic. Many drug molecules can bind to plasma proteins to different extents in vivo, whereas only the free drug can reach the site of action to exert a pharmacological effect and cause toxicity. However, free MTX concentrat...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Dong, Wei-Chong, Guo, Jia-Liang, Wu, Xi-Kun, Zhao, Meng-Qiang, Li, Hao-Ran, Zhang, Zhi-Qing, Jiang, Ye
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2021
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118665/
https://ncbi.nlm.nih.gov/pubmed/33995039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.636975
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