In silico design and in vitro expression of novel multiepitope DNA constructs based on HIV-1 proteins and Hsp70 T-cell epitopes

OBJECTIVES: Epitope-driven vaccines carrying highly conserved and immunodominant epitopes have emerged as promising approaches to overcome human immunodeficiency virus-1 (HIV-1) infection. METHODS: Two multiepitope DNA constructs encoding T cell epitopes from HIV-1 Gag, Pol, Env, Nef and Rev protein...

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Vydáno v:Biotechnol Lett
Hlavní autoři: Akbari, Elahe, Kardani, Kimia, Namvar, Ali, Ajdary, Soheila, Ardakani, Esmat Mirabzadeh, Khalaj, Vahid, Bolhassani, Azam
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2021
Témata:
Original Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118377/
https://ncbi.nlm.nih.gov/pubmed/33987776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10529-021-03143-9
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