Multi-omics approach identifies germline regulatory variants associated with hematopoietic malignancies in retriever dog breeds

Histiocytic sarcoma is an aggressive hematopoietic malignancy of mature tissue histiocytes with a poorly understood etiology in humans. A histologically and clinically similar counterpart affects flat-coated retrievers (FCRs) at unusually high frequency, with 20% developing the lethal disease. The s...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Evans, Jacquelyn M., Parker, Heidi G., Rutteman, Gerard R., Plassais, Jocelyn, Grinwis, Guy C. M., Harris, Alexander C., Lana, Susan E., Ostrander, Elaine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118335/
https://ncbi.nlm.nih.gov/pubmed/33983928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009543
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