Exposure of Platelets to Dengue Virus and Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent Platelet Cell Death and Thrombocytopenia in Mice

In tropical and subtropical regions, mosquito-borne dengue virus (DENV) infections can lead to severe dengue, also known as dengue hemorrhage fever, which causes bleeding, thrombocytopenia, and blood plasma leakage and increases mortality. Although DENV-induced platelet cell death was linked to dise...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Lien, Te-Sheng, Chan, Hao, Sun, Der-Shan, Wu, Jhen-Cheng, Lin, You-Yen, Lin, Guan-Ling, Chang, Hsin-Hou
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118162/
https://ncbi.nlm.nih.gov/pubmed/33995345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.616394
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