Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

BACKGROUND: Restraining maladaptive inflammation is considered a rationale strategy to treat severe coronavirus disease-19 (COVID-19) but available studies with selective inhibitors of pro-inflammatory cytokines have not provided unequivocal evidence of survival advantage. Late administration is com...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Della-Torre, Emanuel, Lanzillotta, Marco, Campochiaro, Corrado, Cavalli, Giulio, De Luca, Giacomo, Tomelleri, Alessandro, Boffini, Nicola, De Lorenzo, Rebecca, Ruggeri, Annalisa, Rovere-Querini, Patrizia, Castagna, Antonella, Landoni, Giovanni, Tresoldi, Moreno, Ciceri, Fabio, Zangrillo, Alberto, Dagna, Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8117339/
https://ncbi.nlm.nih.gov/pubmed/33995419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.675678
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