Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis

Multiple myeloma (MM) is the second most frequent hematologic cancer in the United States. Carfilzomib (CFZ), an irreversible proteasome inhibitor being used to treat relapsed and refractory MM, has been associated with cardiotoxicity, including heart failure. We hypothesized that a multi-omics appr...

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Pubblicato in:Front Cardiovasc Med
Autori principali: Tantawy, Marwa, Chekka, Lakshmi Manasa, Huang, Yimei, Garrett, Timothy J., Singh, Sonal, Shah, Chintan P., Cornell, Robert F., Baz, Rachid C., Fradley, Michael G., Waheed, Nida, DeRemer, David L., Yuan, Lihui, Langaee, Taimour, March, Keith, Pepine, Carl J., Moreb, Jan S., Gong, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Cardiovascular Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116486/
https://ncbi.nlm.nih.gov/pubmed/33996940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2021.645122
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