The Wnt Effector TCF7l2 Promotes Oligodendroglial Differentiation by Repressing Autocrine BMP4-Mediated Signaling

Promoting oligodendrocyte (OL) differentiation represents a promising option for remyelination therapy for treating the demyelinating disease multiple sclerosis (MS). The Wnt effector transcription factor 7-like 2 (TCF7l2) was upregulated in MS lesions and had been proposed to inhibit OL differentia...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhang, Sheng, Wang, Yan, Zhu, Xiaoqing, Song, Lanying, Zhan, Xinhua, Ma, Edric, McDonough, Jennifer, Fu, Hui, Cambi, Franca, Grinspan, Judith, Guo, Fuzheng
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115879/
https://ncbi.nlm.nih.gov/pubmed/33452226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2386-20.2021
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