Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans

Humans are repeatedly exposed to variants of influenza virus throughout their lifetime. As a result, preexisting influenza-specific memory B cells can dominate the response after infection or vaccination. Memory B cells recalled by adulthood exposure are largely reactive to conserved viral epitopes...

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Bibliografski detalji
Izdano u:Sci Transl Med
Glavni autori: Dugan, Haley L., Guthmiller, Jenna J., Arevalo, Philip, Huang, Min, Chen, Yao-Qing, Neu, Karlynn E., Henry, Carole, Zheng, Nai-Ying, Lan, Linda Yu-Ling, Tepora, Micah E., Stovicek, Olivia, Bitar, Dalia, Palm, Anna-Karin E., Stamper, Christopher T., Changrob, Siriruk, Utset, Henry A., Coughlan, Lynda, Krammer, Florian, Cobey, Sarah, Wilson, Patrick C.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115023/
https://ncbi.nlm.nih.gov/pubmed/33298562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abd3601
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