Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network

Biomarker development is a key clinical research need in sickle cell disease (SCD). Hemorheological parameters are excellent candidates as abnormal red blood cell (RBC) rheology plays a critical role in SCD pathophysiology. Here we describe a microfluidic device capable of evaluating RBC deformabili...

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Udgivet i:Front Physiol
Main Authors: Lu, Madeleine, Kanne, Celeste K., Reddington, Riley C., Lezzar, Dalia L., Sheehan, Vivien A., Shevkoplyas, Sergey S.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113687/
https://ncbi.nlm.nih.gov/pubmed/33995119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.633080
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