Valproic Acid Induces Autism-Like Synaptic and Behavioral Deficits by Disrupting Histone Acetylation of Prefrontal Cortex ALDH1A1 in Rats

OBJECTIVES: This study aimed to investigate the impact of valproic acid (VPA) on the histone acetylation of acetaldehyde dehydrogenase 1A1 (ALDH1A1) and the mechanism underlying VPA-induced autism-like behavior. METHODS: Female Sprague-Dawley rats were intraperitoneally injected with VPA during gest...

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Bibliografiske detaljer
Udgivet i:Front Neurosci
Main Authors: Liu, Huan, Tan, Mei, Cheng, Boli, Wang, Si, Xiao, Lu, Zhu, Jiang, Wu, Qionghui, Lai, Xi, Zhang, Qian, Chen, Jie, Li, Tingyu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113628/
https://ncbi.nlm.nih.gov/pubmed/33994921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2021.641284
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