Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae

Multidrug and toxic compound extrusion (MATE) transport proteins confer multidrug resistance on pathogenic microorganisms and affect pharmacokinetics in mammals. Our understanding of how MATE transporters work, has mostly relied on protein structures and MD simulations. However, the energetics of dr...

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Vydáno v:Commun Biol
Hlavní autoři: Raturi, Sagar, Nair, Asha V., Shinoda, Keiko, Singh, Himansha, Bai, Boyan, Murakami, Satoshi, Fujitani, Hideaki, van Veen, Hendrik W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113278/
https://ncbi.nlm.nih.gov/pubmed/33976372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02081-6
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