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Nanoparticles displaying allergen and Siglec-8 ligands suppress IgE-FcεRI mediated anaphylaxis and desensitize mast cells to subsequent antigen challenge
Siglec-8 is an inhibitory receptor expressed on eosinophils and mast cells. Here we took advantage of a novel Siglec-8 transgenic mouse model to assess the impact of modulating IgE dependent mast cell degranulation and anaphylaxis using a liposomal platform to display an allergen with or without a s...
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| Publicat a: | J Immunol |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113104/ https://ncbi.nlm.nih.gov/pubmed/33911007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901212 |
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