Nanoparticles displaying allergen and Siglec-8 ligands suppress IgE-FcεRI mediated anaphylaxis and desensitize mast cells to subsequent antigen challenge

Siglec-8 is an inhibitory receptor expressed on eosinophils and mast cells. Here we took advantage of a novel Siglec-8 transgenic mouse model to assess the impact of modulating IgE dependent mast cell degranulation and anaphylaxis using a liposomal platform to display an allergen with or without a s...

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Vydáno v:J Immunol
Hlavní autoři: Duan, Shiteng, Arlian, Britni M., Nycholat, Corwin M., Wei, Yadong, Tateno, Hiroaki, Smith, Scott A., Macauley, Matthew S., Zhu, Zhou, Bochner, Bruce S., Paulson, James C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113104/
https://ncbi.nlm.nih.gov/pubmed/33911007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901212
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