A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection

Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus with latent and lytic cycles. EBV replicates in the stratified epithelium but the nasopharynx is also composed of pseudostratified epithelium with distinct cell types. Latent infection is associated with nasopharyngeal carcinoma (NPC). Here, we...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Ziegler, Phillip, Tian, Yarong, Bai, Yulong, Abrahamsson, Sanna, Bäckerholm, Alan, Reznik, Alex S., Green, Anthony, Moore, John A., Lee, Stella E., Myerburg, Michael M., Park, Hyun Jung, Tang, Ka-Wei, Shair, Kathy Ho Yen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8112674/
https://ncbi.nlm.nih.gov/pubmed/33914843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009041
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