Raloxifene inhibits the overexpression of TGF-β1 in cartilage and regulates the metabolism of subchondral bone in rats with osteoporotic osteoarthritis

Overexpression of transforming growth factor-beta 1 (TGF-β1) and subchondral bone remodeling play key roles in osteoarthritis (OA). Raloxifene (RAL) reduces the serum level of TGF-β1 in postmenopausal women. However, the effect of RAL on TGF-β1 expression in articular cartilage remains unclear. Ther...

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Bibliographische Detailangaben
Veröffentlicht in:Bosn J Basic Med Sci
Hauptverfasser: Ping, Shao-Hua, Tian, Fa-Ming, Liu, Hao, Sun, Qi, Shao, Li-Tao, Lian, Qiang-Qiang, Zhang, Liu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8112563/
https://ncbi.nlm.nih.gov/pubmed/33259777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.17305/bjbms.2020.5142
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