Serum Epitope Repertoire Analysis Enables Early Detection of Lyme Disease with Improved Sensitivity in an Expandable Multiplex Format

Widely employed diagnostic antibody serology for Lyme disease, known as standard two-tier testing (STTT), exhibits insufficient sensitivity in early Lyme disease, yielding many thousands of false-negative test results each year. Given this problem, we applied serum antibody repertoire analysis (SERA...

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Bibliographic Details
Published in:J Clin Microbiol
Main Authors: Reifert, Jack, Kamath, Kathy, Bozekowski, Joel, Lis, Ewa, Horn, Elizabeth J., Granger, Dane, Theel, Elitza S., Shon, John, Sawyer, Jaymie R., Daugherty, Patrick S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Immunoassays
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111119/
https://ncbi.nlm.nih.gov/pubmed/33148704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01836-20
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