Reduced SKP1 and CUL1 expression underlies increases in Cyclin E1 and chromosome instability in cellular precursors of high-grade serous ovarian cancer

BACKGROUND: High-grade serous ovarian cancer (HGSOC) is the most common and lethal ovarian cancer histotype. Chromosome instability (CIN, an increased rate of chromosome gains and losses) is believed to play a fundamental role in the development and evolution of HGSOC. Importantly, overexpression of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Cancer
Egile Nagusiak: Lepage, Chloe Camille, Palmer, Michaela Cora Lynn, Farrell, Ally Catherina, Neudorf, Nicole Marie, Lichtensztejn, Zelda, Nachtigal, Mark William, McManus, Kirk James
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8110794/
https://ncbi.nlm.nih.gov/pubmed/33731859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-021-01317-w
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